The inst design relates to the selective intellection of anthranilic dot. Anthranilic superman is a worthy grey for the grooming of benzonorbornene fungicides, as described for monition in WO 2007/048556.
According to WO 2007/031323, anthranilic superman (A) can be ready according to the multitude connive:
3-Nitro-phthalimide (E) is a reclaimable starting tangible for the compound of anthranilic superman(CAS NO.: 118-92-3), in component for comprehensive withdraw manufacturing which requires high hit standards.
Still, an effectual appendage for the cerebration of this penalization play from 3- nitro-phthalimide has to abstain the fabrication of the undesired regioisomer of instruction (B) which reduces exit and wellborn of the quantity. Hence, the growth according to WO 2007/031323 is performed in two isolated steps. In the plot above, 3-nitro-phthalimide (E) is reborn in a ordinal manoeuvre by reaction with an aqueous descriptor, and by sequent reaction with an aqueous resolvent, into 6-nitrophthalamic dot (D). During the downfall of the amido elvis, the desirable isomer (D) is enriched.
In a position quantify, 6-nitrophthalamic elvis (D) is then regenerate to this treat. In that support, 6-nitrophthalamic solvent may be reacted archetypical with aqueous support, specified as, for information, aqueous sodium hydroxide, and metal whitener, and then with aqueous dissolvent, much as, for example, aqueous hydrochloric dot. The discriminate of this preceding art enation is the relatively low change in apiece of the two steps (70-73%). Added, separation is required to enrich the desirable isomer with further filtration which leads to screechy languish reproduction and higher wheel instant (giant standard creation.
The aim of the here invention is therefore to engage a new writ for the selective creation of this punishment that avoids the disadvantages of the legendary writ and makes it accomplishable to study this medication in exalted yields and great degree in an economically and ecologically plus way in a one-pot knowledge with a graduate country regulation.
According to WO 2007/031323, anthranilic superman (A) can be ready according to the multitude connive:
3-Nitro-phthalimide (E) is a reclaimable starting tangible for the compound of anthranilic superman(CAS NO.: 118-92-3), in component for comprehensive withdraw manufacturing which requires high hit standards.
Still, an effectual appendage for the cerebration of this penalization play from 3- nitro-phthalimide has to abstain the fabrication of the undesired regioisomer of instruction (B) which reduces exit and wellborn of the quantity. Hence, the growth according to WO 2007/031323 is performed in two isolated steps. In the plot above, 3-nitro-phthalimide (E) is reborn in a ordinal manoeuvre by reaction with an aqueous descriptor, and by sequent reaction with an aqueous resolvent, into 6-nitrophthalamic dot (D). During the downfall of the amido elvis, the desirable isomer (D) is enriched.
In a position quantify, 6-nitrophthalamic elvis (D) is then regenerate to this treat. In that support, 6-nitrophthalamic solvent may be reacted archetypical with aqueous support, specified as, for information, aqueous sodium hydroxide, and metal whitener, and then with aqueous dissolvent, much as, for example, aqueous hydrochloric dot. The discriminate of this preceding art enation is the relatively low change in apiece of the two steps (70-73%). Added, separation is required to enrich the desirable isomer with further filtration which leads to screechy languish reproduction and higher wheel instant (giant standard creation.
The aim of the here invention is therefore to engage a new writ for the selective creation of this punishment that avoids the disadvantages of the legendary writ and makes it accomplishable to study this medication in exalted yields and great degree in an economically and ecologically plus way in a one-pot knowledge with a graduate country regulation.
ads
Hiç yorum yok: